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Lauffenburger Lab


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Nancy Guillen (BE doctoral) EmailCV

Role of microRNAs in intracellular signaling networks regulating hepatocellular carcinoma cell behavior

Experimental studies of IFNgamma and TRAIL-induced microRNAs in a hepatocellular carcinoma (HCC) cell line to determine the role of these miRNAs in the apoptotic response. The goal is to find correlations between cell phenotypic behavior and changes in expression of specific microRNAS. These microRNAs target proteins involved in signaling pathways that are relevant for the cell death response. Using quantitative methods for obtaining time dependent data on microRNA and cell death measurements, we can develop a predictive mathematical model to describe cell behavior in response to a combination treatment with IFNgamma and TRAIL.